سم شناسی نانومواد

نوع مقاله : مقاله ترویجی

نویسندگان

1 گروه نانوفناوری پزشکی، دانشکده علوم و فن آوری های نوین پزشکی، دانشگاه علوم پزشکی شیراز،ایران.

2 گروه نانوفناوری پزشکی، دانشکده علوم و فن آوری های نوین پزشکی، دانشگاه علوم پزشکی شیراز مرکز تحقیقات نانوفناوری در علوم زیستی و پزشکی، دانشگاه علوم پزشکی شیراز. گروه فیزیک پزشکی، دانشکده پزشکی، دانشگاه علوم پزشکی شیراز.

3 گروه نانوفناوری پزشکی، دانشکده علوم و فن آوری های نوین پزشکی، دانشگاه علوم پزشکی شیراز مرکز تحقیقات نانوفناوری در علوم زیستی و پزشکی، دانشگاه علوم پزشکی شیراز. گروه فیزیک پزشکی، دانشکده پزشکی، دانشگاه علوم پزشکی شیراز

چکیده

در سال های اخیر گسترش نانوفناوری سبب شده است تا هرچه بیشتر از نانومواد استفاده شده و این مواد نهایتا» در محیط زیست رهاسازی شوند. بنابراین قبل از استفاده از این مواد در محیط های زیستی و زنده باید از نظر سازگاری زیستی ارزیابی شوند. اثرات سمی نانومواد بر موجودات زنده و محیط زیست توسط محققان مورد بررسی قرار گرفته است، اما هنوز ابهاماتی درباره اثرات و ساز و کار سمی بودن نانومواد وجود دارد. ویژگی های منحصر به فرد نانومواد و چگونگی واکنش آنها با سامانه های زیستی، معیار استفاده ایمن از نانومواد می باشد. ویژگی های نانومواد از قبیل اندازه، شکل، نسبت ابعاد، تراکم و نقوص سطحی علت سمی سازی سلولی و عوارض جانبی این مواد است. نانومواد می توانند منجر به بروز طیف وسیعی از اثرات حاد و مزمن مانند التهاب، تشدید بیماری آسم، و سرطان شود.

کلیدواژه‌ها


عنوان مقاله [English]

Toxicology of Nanomaterials

نویسندگان [English]

  • Amid Rahi 1
  • Naghmeh Sattarahmadi 2
  • Hossein Heli 3
1 Department of Nanomedicine, School of Advanced Medical Sciences and Technologies, Shiraz University of Medical Sciences, Shiraz, Iran.
2 Department of Nanomedicine, School of Advanced Medical Sciences and Technologies, Shiraz University of Medical Sciences, Shiraz, Iran. Nanomedicine and Nanobiology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran. Department
3 Department of Nanomedicine, School of Advanced Medical Sciences and Technologies, Shiraz University of Medical Sciences, Shiraz, Iran. Nanomedicine and Nanobiology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran. Department
چکیده [English]

In recent years, developments in nanotechnology have led to more widespread use of nanomaterials and these materials are finally released to the environment. Therefore, before employing nanomaterials in biological and environmental medium, the biocompatibility of these materials must be evaluated. Toxic effects of nanomaterials on the living organisms and environment has been studied by many researchers, however, there are still uncertainties about the effects and mechanisms of nanomaterials toxicity. The unique characteristics of nanomaterials and their interaction with biological systems are criteria for the safe using these materials. Nanomaterial properties such as size, shape, aspect ratio, density and surface effects cause to cell toxicity and symptom effects. Nanomaterials can cause a range of acute and chronic effects such as inflammation, exacerbation of asthma and cancer.

کلیدواژه‌ها [English]

  • Nanomaterials
  • Nanotechnology
  • Toxicity
  • Safety
  • biocompatibility
  • Nanobiomaterials
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