Translational Medicine: A New Global Scientific Competition

Document Type : Promotion Article

Authors

1 National Institutes of Health, Ministry of Health, USA

2 Institute of Biochemistry and Biophysics, University of Tehran, Tehran, Iran.

3 Institute of Biochemistry and Biophysics, University of Tehran,Tehran, Iran

Abstract

After the completion of human genome sequencing in 2003, the field of translational medicine was created to expedite the conversion of the basic and clinical research into effective therapy and medical devices applicable for patient care. Translational medicine is the synergy between epidemiology, basic and clinical research with diversified impacts on the institutions, clinicians, scientists, patients, investors, policy makers and general public. Current scientific vision is somehow different from the traditional research direction. The difference is the enhanced awareness about the difficulties of reaching scientific goals. These difficulties include scientific challenges, outdated infrastructures, cost, licensing, and length of clinical testing and lack of well-trained scientists that all could affect the medical application. Despite the shortcomings, future of translational medicine is still promising by providing highly trained translational research scientists that can engage with patient, laboratory, industry and government. Most developed countries are going forward strongly by investing on their trained scientists and suitable scientific projects which will warrant a profitable future.  In this article, we will discuss the processes, obstacles, opportunities and challenges of translational medicine in countries where they are undisputed scientific leaders in this field in comparison with Islamic Republic of Iran.

Keywords


[1]. Pauling, L., Itano, H., Singer, S.J., Wells, I. (1949)."Sickle Cell Anemia, a Molecular Disease", Science, Vol.110, pp. 543-548.
[2]. Watson, J.D., Crick, F. (1953). "Molecular Structure of Nucleic Acids: A Structure for Deoxyribose Nucleic Acid", Nature, Vol.171, pp. 737–738.
[3]. Littman, B.H., DiMario. L., Plebani, M., Marincola, F.M.(2007). "What’s Next in Translational Medicine?", Clinical Science, Vol. 112, pp. 217-227.
[4]. Baird, P. (2001). "The Human Genome Project, Genetics and Health", Community Genetics, Vol. 4 (2), pp. 77–80.
[5]. Manolio, T.A. (2010). "Genome Wide Association Studies and Assessment of the Risk of Disease", New England Journal Medicine, Vol. 363, pp. 166-176.
[6]. Horig, H., Marincola, E., Marincola, F.M. (2005)."Obstacles and Opportunities in Translational Research", Nature Medicine, Vol. 11, pp. 705-708.
[7]. Mankoff, S.P., Brander, C., Ferrone, S., Marincola, F.M. (2004). "Lost in Translation: Obstacles to Translational Medicine", Journal of Translational Medicine, Vol. 2, P. 14.
[8]. Zerhouni, E.A. (2005)."Translational and Clinical Science-Time for a New Vision". New England Journal of Medicine, Vol. 353, pp. 1621-1623.
[9]. Bajaj, A., Desai, M. (2006). "Challenges and Strategies in Novel Drug Delivery Tchnologies",Pharmaceutical Times, Vol. 38, pp. 12-16.
[10]. Lord, G.M., Snape, K., Trembath, R.C. (2008)."Translational Medicine and the NIHR Biomedical Research Centre concept", Qjm-an International Journal of Medicine, Vol. 101, pp. 901-906.
[11]. Wang, X., Wang, E., Marincola, F.M. (2011). "Translational Medicine is Developing in China: a New Venue for Collaboration", Journal of Translational Medicine, Vol. 4, p. 3.
[12]. Collins, F.S.(2011). "Reengineering Translational Science: the Time is Right", Sci Translational Medicine. Vol.3, pp. 90-94.
[13].Yock, P.G., T.J. Brinton, Zenios, S.A. (201)." Teaching Biomedical Technology Innovation as a Discipline", Sci Transl Med. Vol.3, pp. 92-98.
[14]. Paul, S.M., et al.(2010). "How to Improve R&D Productivity: the Pharmaceutical Industry’s Grand Challenge", Nat Rev Drug Discovery. Vol. 9: pp. 203-214.