رضایت از زندگی و آزادسازی اکسی توسین (هورمون عصبی شیمیایی )در مغز

نوع مقاله : ترجمه و جمعبندی


1 دانشگاه تهران، مرکز تحقیقات بیوشیمی بیوفیزیک

2 مرکز تحقیقات بیوشیمی و بیوفیزیک، دانشگاه تهران، تهران، ایران

3 French National Institute for Agriculture, Food, and Environment (INRAE)

4 INRAE · Biopolymères, Interactions, Assemblages (BIA), Nantes, France


رضایت از زندگی بیانگر نگرش مثبت فرد نسبت به جهانی است که در آن زندگی می­کند و به متغیرهای متفاوتی بستگی دارد که یک سوی این نیازها به اجتماع و سوی دیگر آن به شخص برمی­گردد. بررسی جوانب مختلف ایجاد رضایت از زندگی از طریق علوم مختلف صورت گرفته و هر یک از آنها پایه­های اساسی و متمایزی را در این مسیر مشخص کرده­اند. بررسی سیستم­های بیولوژیکی حاکی از وجود عوامل زیست-شیمی مؤثر در بروز رفتارهایی بوده که در نیل به رضایت از زندگی و احساس ارزشمندی مؤثر می‌باشند. ردیابی مکانیسم­های خاص در افراد با سنین مختلف می­تواند زمینه­ساز شناسایی دقیق عوامل مؤثر در بروز این ویژگی­ها گردد.
رضایت از زندگی در ارتباط با ترکیبات عصبی-شیمیایی مغز می­باشد. اکسی­توسین-سروتونین-دوپامین به‌عنوان هورمو­ن­های شادی شناخته شد­ه­اند که افزایش آنها در روابط اجتماعی باعث می­شود فرد موجی از احساسات مثبت را دریافت کند. اکسی­توسین یک هورمون 9 اسیدآمینه­ای بوده که در هیپوتالاموس سنتز شده و نقش مرکزی در تنظیم زایمان و شیردهی دارد. فعال­شدن گیرنده­های اکسی­توسین باعث ایجاد یک آبشار پایین­دستی و افزایش کلسیم داخل سلولی در میوفیبریل­های رحم می­شود که نهایتاً این امر باعث تقویت و افزایش دفعات انقباضات خواهد شد. همچنین اکسی­توسین به‌عنوان یک نوروپپتید چندعملکردی زمینه را برای بروز رفتارهای سخاوت، اعتماد و روابط نوع‌دوستانه فراهم می­کند که محصول این رفتارها در سنین بالا، القای رضایت از زندگی و احساس ارزشمندی در افراد می باشد.
ارتباط چندجانبه سیستم های زیستی- باورهای معنوی و رضایت از زندگی مسئله بسیار جالب توجهی بوده که نیازمند نگرشی کامل در جهت شناسایی جوانب مختلف آن است. شناسایی بسترهای عصبی- شیمیایی رفتارهای اجتماعی افراد در سنین مختلف می­تواند زمینه­ساز دستیابی به نتایج روشن در نحوه ایجاد رضایت از زندگی و ارتباط آن با بهزیستی شود.


عنوان مقاله [English]

Life Satisfaction and The Release of Oxytocin in The Brain as A Neurochemical Hormone

نویسندگان [English]

  • Somayyeh Ghareghomi 1
  • Ali Akbar Moosavi-Movahedi 2
  • Thomas Haertle 3 4
1 University of Tehran, IBB
2 Institute of Biochemistry and Biophysics, University of Tehran, Tehran, Iran.
3 French National Institute for Agriculture, Food, and Environment (INRAE) | INRAE · Biopolymères, Interactions, Assemblages (BIA), Nantes, France
4 French National Institute for Agriculture, Food, and Environment (INRAE) | INRAE · Biopolymères, Interactions, Assemblages (BIA), Nantes, France
چکیده [English]

Life satisfaction expresses a positive attitude towards the world in which one lives and depends on various variables, one of which is related to the community and the other to the individual. Various aspects of creating life satisfaction through various sciences have been studied, and each has identified basic and distinct bases in this direction. The study of biological systems indicates the existence of biochemical factors affecting the occurrence of behaviors that are effective in achieving life satisfaction and a sense of worth. Tracing the mechanisms of occurrence of specific features in people of different ages can be the basis for accurately identifying factors affecting these features.
Life satisfaction is related to brain neurochemicals. Oxytocin-Serotonin-Dopamine is known as happiness hormones, whose increase in social relationships makes a person receive a wave of positive emotions. Oxytocin (OT) is a nonapeptide hormone that is central in regulating parturition and lactation. Oxytocin receptor activation triggers several downstream signaling pathways and increases intracellular calcium in uterine myofibrils, ultimately strengthening and increasing the frequency of contractions.
This hormone as a multifunctional neuropeptide by reducing the level of stress and anxiety and creating physiological stability provides the basis for generosity, trust and altruistic behaviors that the product of these behaviors in old age is to induce life satisfaction and feelings of worth in people.
The multifaceted relationship between biological systems-spiritual beliefs and life satisfaction is an exciting issue that requires a complete approach to identify its various aspects. Identifying the neurochemical basis of social behaviors of people of different ages can pave the way for achieving precise results in how to create life satisfaction and its relationship with well-being

کلیدواژه‌ها [English]

  • Life satisfaction
  • Spiritual beliefs
  • Oxytocin
  • Social manner
  • Well-being
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